I never thought about it before but I use upstream and downstream without much though. For my personal devices and containers I use Fedora but when it comes to servers and VMs I use Debian for its stable nature.
I also run Linux mint in my homelab with pcie pass though so it functions like a normal desktop.
I just stick with one because I’m boring. I’ve used it for a long time, it works, I haven’t really changed anything in years. I think it’s pretty cool to talk with people who are polydistroamorous though.