Best answer, thx

Hm

Because Guix has better configuration syntax, it will not function properly without systemd, as I understand it.

Already seen

Im already using fork of picom:)

Soo, if i want to use timeshift i will need polkit,so what about it?

The main reason is that I don’t know how to run background programs like pipewire normally.

If you do it via xinitrc, it will work only for one user.

Also I’m not sure that for example vscodium or lightdm
without dbus.

Also DE automounting usb drives

I don’t want to steal DE’s job :)

Just use session manager like lxsession

I don’t want to autostart all programs by myself, most of DE control autostart and dbus session by it self… Furthermore,DEs are contain settings manager etc

What about lxqt customization?

pycharm and notepad++