For frame rate, I would recommend the settings presented in this video. The video has chapters, so you can jump straight to the recommended setting section. They include battery saver, recommended (40fps), or prettiest (30fps). The higher fps setting may help with combat, but the game is meant to be hard and very punishing. A lot of the game comes from trial and error, and steadily improving your playing and pattern recognition.

For messages, it’s possible a graphical setting might help, but otherwise the deck has a built in magnification tool that may help you. Normally you hold down either the steam button or the “. . .” Button and then press L1 to turn on the magnifier, but if you’re using it frequently you can also bind one of the back buttons to magnify. I would also recommend setting some of the back buttons to toggle between potions and drink them, I found that to be very helpful when playing.