In general yes. However, the popularization of the two handed “weaver” pistol stance is quite modern, rising to prominence in the 60s and 70s. Until then, pistol technique focused almost entirely on using a single handed grip. Military, police etc were all taught to use one hand.

The US government even defines a pistol as “a weapon originally designed, made, and intended to fire a projectile (bullet) from one or more barrels when held in one hand”, which is a relic from an earlier era.

The rules in Olympic pistol shooting limit shooting to one hand because they are like Olympic fencing and many martial arts disciplines. It traces its root to combat arts. However, it’s now a unique sport with esoteric rules and techniques that divorce it from any practical usage.