I personally think each of the challenges are well thought out!
Favourites: Badder Bosses and Swarm Intelligence. These imho add a nice layer to the game.
Least favourite: Into the darkness, it annoys me getting sniped from a ranged enemy without seeing anything.
Special shout-out to pharmacopoeia and faith is my armour. I cannot finish the game with these on - anyone got any tips?
I like badder bosses, swarm int and runes quite a bit. Hostile champs keeps you on your toes and pulls enough random bullshit that it’s a constant challenge paired with the above.
I don’t really like barren land, I find removing mechanics like plants unfun.