But back in the day “good” was mostly absence of parasites.
Well, relatively speaking anyhow. Just about everybody had them, it was more of a question of which parasites and how many – and this was largely how things were up until indoor toilets & plumbing became more common and of course still is in many areas.
Funnily enough our immune systems sort of co-evolved with some intestinal parasites, and not having parasites is one factor in people developing autoimmunity. Some autoimmune diseases can even be treated to some extent by purposefully giving you some specific parasite (can’t remember which one, too lazy to search)
An autoimmune disease is when your body attacks itself, and it’s possible giving yourself a parasite gives it something else to focus on…
But man, that sounds like when people gave themselves tapeworms to lose weight. There was some vague logic to make it sound ok. But any medical professional that condoned it probably wasn’t a very good doctor.
Especially if they are infecting people to treat autoimmune disorders
An autoimmune disease is when your body attacks itself, and it’s possible giving yourself a parasite gives it something else to focus on…
It’s more complex than that. If someone is exposed to parasites when they’re still developing, their chances of having autoimmune issues later in life goes down – the fancy way to say that is that exposure to some parasites lessens the chances of immune system dysregulation. Some parasite proteins can also be used to modulate the immune system to eg. treat asthma. See eg. Helminth Immunomodulation in Autoimmune Disease from 2017, abstract here:
Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.
But man, that sounds like when people gave themselves tapeworms to lose weight. There was some vague logic to make it sound ok. But any medical professional that condoned it probably wasn’t a very good doctor.
Especially if they are infecting people to treat autoimmune disorders
Just because giving someone a tapeworm for weight loss is not a great idea doesn’t really mean anything here. Immunomodulatory therapy with parasites isn’t woo-woo despite how weird it may sound, and the idea isn’t to necessarily give people worms (although that’s not entirely ruled out either!) but to learn how they do what they do
There have already been attempts to treat immune-mediated diseases by artificially infecting them with helminths. Because Trichuris suis can be obtained from experimentally infected pigs, the parasite has been used in immunotherapy research to artificially infect people. There are some clinical reports that patients who ingested T. suis had a reduction in several immune disorders such as Crohn’s disease (73) and ulcerative colitis (74). However, some clinical trials have shown no therapeutic effect (75, 76) and in a large study using meta-analysis, T. suis showed no apparent benefit for inflammatory bowel disease patients (77). Besides, therapeutic benefit by parasites may be limited to the infection sites but not systemic. A clinical trial of artificial infection with T. suis, a parasite of the intestine, did not provide relief from allergic rhinitis (78). Furthermore, infection with live parasites for therapeutic use may not be practical, and can sometimes cause other unintended consequences. There is also a risk of inadvertently transmitting pathogenic parasites. For this reason, it is imperative to identify immunomodulatory molecules and apply them to treatment of immune-mediated diseases rather than using live parasites. In order to ensure safety, it is also necessary to elucidate the detailed mechanism of how the molecule regulates immunity.
Well, relatively speaking anyhow. Just about everybody had them, it was more of a question of which parasites and how many – and this was largely how things were up until indoor toilets & plumbing became more common and of course still is in many areas.
Funnily enough our immune systems sort of co-evolved with some intestinal parasites, and not having parasites is one factor in people developing autoimmunity. Some autoimmune diseases can even be treated to some extent by purposefully giving you some specific parasite (can’t remember which one, too lazy to search)
I mean, kind of?
An autoimmune disease is when your body attacks itself, and it’s possible giving yourself a parasite gives it something else to focus on…
But man, that sounds like when people gave themselves tapeworms to lose weight. There was some vague logic to make it sound ok. But any medical professional that condoned it probably wasn’t a very good doctor.
Especially if they are infecting people to treat autoimmune disorders
It’s more complex than that. If someone is exposed to parasites when they’re still developing, their chances of having autoimmune issues later in life goes down – the fancy way to say that is that exposure to some parasites lessens the chances of immune system dysregulation. Some parasite proteins can also be used to modulate the immune system to eg. treat asthma. See eg. Helminth Immunomodulation in Autoimmune Disease from 2017, abstract here:
Just because giving someone a tapeworm for weight loss is not a great idea doesn’t really mean anything here. Immunomodulatory therapy with parasites isn’t woo-woo despite how weird it may sound, and the idea isn’t to necessarily give people worms (although that’s not entirely ruled out either!) but to learn how they do what they do
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977410/
You’re right that people are trying it.
I never said no one was, I said only shitty doctors would prescribe it.
I didn’t see anything about it being prescribed, but there have been studies.
The studies just show it doesn’t work.