To date, more and more European cities are systematically working to expand the proportion of their street network with a speed limit of 30 km/h. This paper endeavored to assess the effectiveness of city-wide 30 km/h speed limits in Europe. In an effort to condense research outputs, a quantitative approach along with qualitative assessments were implemented. This study described the changes in safety, environment, energy, traffic, livability, and health before and after the phased implementation of city-wide 30 km/h speed limits. The systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results from 40 different cities across Europe, including Brussels, Paris, and Zurich, indicated that reductions in speed limits improved road safety by decreasing the likelihood of crash risk and the severity of crashes that do occur. On average, the implementation of 30 km/h speed limits in European cities demonstrated a 23%, 37%, and 38% reduction in road crashes, fatalities, and injuries, respectively. Lower speed limits also yielded environmental benefits, with emissions decreasing on average by 18%, noise pollution levels by 2.5 dB, and fuel consumption by 7%, indicating enhanced fuel efficiency and reduced environmental impact. Encouraging citizens to embrace walking, cycling and utilizing public transit services can further contribute to a safer and environmentally sustainable urban environment.